Variance Components Analysis in Heritability Studies

Variance components, heritability estimates, and breeding values for performance test traits in Old Kladruber horses

The Old Kladruber horse is an important Czech genetic resource. In the current study, two categories of traits were evaluated – the first, a numerical score for Type and Gender Expression and the second, 11 traits describing performance divided into four categories: (1) Rideability (Overall Impression, Rideability), (2) Gaits (Walk, Trot, Canter), (3) Carriage Drivability (Dressage Test, Obstac...

Estimation of Epistatic Variance Components and Heritability in Founder Populations and Crosses

Genetic association studies have explained only a small proportion of the estimated heritability of complex traits, leaving the remaining heritability "missing." Genetic interactions have been proposed as an explanation for this, because they lead to overestimates of the heritability and are hard to detect. Whether this explanation is true depends on the proportion of variance attributable to g...

Estimating Variance Components in Functional Linear Models with Applications to Genetic Heritability

Quantifying heritability is the first step in understanding the contribution of geneticvariation to the risk architecture of complex human diseases and traits. Heritabilitycan be estimated for univariate phenotypes from non-family data using linear mixedeffects models. There is, however, no fully developed methodology for defining orestimating heritability from longitudinal ...

Variance components linkage analysis with repeated measurements.

BACKGROUND When subjects are measured multiple times, linkage analysis needs to appropriately model these repeated measures. A number of methods have been proposed to model repeated measures in linkage analysis. Here, we focus on assessing the impact of repeated measures on the power and cost of a linkage study. METHODS We describe three alternative extensions of the variance components appro...

Variance Components